Interpretation of quantiative LA-ICP-MS mapping of phase segregation in glass entails separation of differences in phase chemistry from effects due to material loading into the plasma during analysis. The present study evaluates two-domain lead-arsenic murrina glass consisting of transparent soda-lime-silica glass and an opaque Pb-As-rich white glass. The primary focus is on the possibility of separating phase chemistry from material-loading effects based on differences between material introduction during LA-ICP-MS mapping of the two domains. Data for transparent and white domains includes instrumental parameters, calibrated LA-ICP-MS concentrations, normalized LA-ICP-MS concentrations, SEM-EDXS data, depth measurement, density estimate, concentration ratios, and loading factors. The white domain had a depth-density product loading factor of 6.34 while that of the transparent domain was 3.11, giving a 2.04 times larger loading factor for material introduction. The material loading effect was significantly lower compared to the observed difference in chemical composition. Arsenic concentration rose from 0.319 ± 0.024 % in the transparent glass to 4.88 ± 0.27 % in the white glass, and lead attained a concentration of 31.12 ± 1.31 % in the white phase. Conversely, calcium concentration was higher in the transparent phase compared to the white phase by a ratio of 0.18. Barium remained a minor component as it could not be accurately quantified by SEM-EDXS. It is concluded that the current study confirms that material loading information can separate phase chemistry from physical effects using SEM-EDXS and LA-ICP-MS concentration maps and ablation depth.